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dc.contributor.authorRošul, Milana
dc.contributor.authorĐerić, Nataša
dc.contributor.authorMišan, Aleksandra
dc.contributor.authorPojić, Milica
dc.contributor.authorŠimurina, Olivera
dc.contributor.authorHalimi, Charlotte
dc.contributor.authorNowicki, Marion
dc.contributor.authorCvetković, Biljana
dc.contributor.authorMandić, Anamarija
dc.contributor.authorReboul, Emmanuelle
dc.date.accessioned2023-07-11T13:13:10Z
dc.date.available2023-07-11T13:13:10Z
dc.date.issued2022-08-15
dc.identifier.citationRošul, M., Đerić, N., Mišan, A., Pojić, M., Šimurina, O., Halimi, C., ... & Reboul, E. (2022). Bioaccessibility and uptake by Caco-2 cells of carotenoids from cereal-based products enriched with butternut squash (Cucurbita moschata L.). Food Chemistry, 385, 132595.en_US
dc.identifier.issn0308-8146
dc.identifier.urihttp://oa.fins.uns.ac.rs/handle/123456789/168
dc.description.abstractEnriching cereals-based products with bioactive compounds is a valuable strategy to improve product quality. We studied carotenoid bioaccessibility and intestinal uptake from a pumpkin-enriched porridge, cookies and sponge cakes by using in vitro digestion coupled with Caco-2 cell uptake. Among the carotenoids recovered in different products, α-carotene was the most important abundant one. However, lutein displayed a significantly higher bioaccessibility compared to α-carotene and β-carotene in baked products (up to 10.28% compared to 1.22% and 0.88%, respectively). α-Carotene was the only carotenoid recovered in Caco-2 cells after micelle incubation. Cookie micelles led to the highest percentage of α-carotene cell uptake (2.33% and 1.38% for cookies with butter and cookies with vegetable oil, respectively) compared to the other baked products, followed by dry pumpkin puree micelles (1.31%). Overall, our data show that both bioaccessiblity and cell uptake of carotenoids from cereal-based products are variable and highly depend on food formulation and structure.en_US
dc.description.sponsorshipThis research was funded by: -The Ministry of Education, Science and Technological Development of the Republic of Serbia (Contract No: 451-03-9/2022-14/200222), The Science Fund of the Republic of Serbia, PROMIS, Grant No. 6060592, DEStiny; -The French Ministry of higher education, research and innovation (Exchange program Hubert Curien Pavle Savić 2018-2019), -COST Action “European network to advance carotenoid research and applications in agro-food and health” EUROCAROTEN, CA15136, www.eurocaroten.eu, http://www.cost.eu/COST_Actions/ca/CA15136) supported by COST.en_US
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.rightsembargoedAccess
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectIn vitro Digestionen_US
dc.subjectMicellesen_US
dc.subjectEnterocytesen_US
dc.subjectBioavailabilityen_US
dc.subjectPumpkinen_US
dc.titleBioaccessibility and uptake by Caco-2 cells of carotenoids from cereal-based products enriched with butternut squash (Cucurbita moschata L.)en_US
dc.typeinfo:eu-repo/semantics/articleen_US
dcterms.relationinfo:eu-repo/grantAgreement/ScienceFundRS/Promis/6060592/RS//
dc.identifier.scopus2-s2.0-85126789018
dc.identifier.wos000794033800005
dc.identifier.doi10.1016/j.foodchem.2022.132595


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