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dc.contributor.authorErceg, Tamara
dc.contributor.authorBrakus, Gaja
dc.contributor.authorStupar, Alena
dc.contributor.authorCvetinov, Miroslav
dc.contributor.authorHadnađev, Miroslav
dc.contributor.authorRistić, Ivan
dc.date.accessioned2023-07-13T13:19:56Z
dc.date.available2023-07-13T13:19:56Z
dc.date.issued2022-05-16
dc.identifier.citationErceg, T., Brakus, G., Stupar, A., Cvetinov, M., Hadnađev, M., & Ristić, I. (2022). Synthesis and Characterization of Chitosan-Acrylic Acid Based Hydrogels and Investigation the Properties of Bilayered Design With Incorporated Alginate Beads. Journal of Polymers and the Environment, 30, 3737–3760.en_US
dc.identifier.issn1572-8919
dc.identifier.urihttp://oa.fins.uns.ac.rs/handle/123456789/229
dc.description.abstractThe paper presents the synthesis of hydrogels via free-radical polymerization, based on Chitosan (CS) grafted with Acrylic acid (AA), using a two-step procedure. Free-radical polymerization has given strong hydrogels with compact structure, dominant elastic behavior, and long linear viscoelastic region. The results of rheological studies have shown that obtained hydrogels have significantly improved mechanical properties in comparison to chitosan hydrogels obtained by other sustainable methods. A step forward in the investigation of the potential application of chitosan hydrogels in wound dressing systems has been made by preparation of the bilayer design by embedding a layer of active compound-loaded alginate beads into the contact surface between two conjoined units of CS/AA hydrogels. Wild garlic (Allium ursinum L.) dried extract was used as an active compound because of its antimicrobial activity and green properties. This system has demonstrated pH-dependent release of extract and higher shear elastic modulus values than ordinary disc gels. A conducted study has given preliminary results for the possible application of bilayer chitosan-based hydrogels in wound dressing systems and represents the first step towards extrapolating the proposed design across other application fields.en_US
dc.description.sponsorshipThis study was supported by Ministry of Education, Science and Technological Development, Republic of Serbia, project number 451-03-68/2020-14/ 200134 for financial support.en_US
dc.language.isoenen_US
dc.publisherSpringer Natureen_US
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200134/RS//
dc.rightsembargoedAccess
dc.subjectChitosan hydrogelsen_US
dc.subjectFree-radical polymerizationen_US
dc.subjectAlginate beadsen_US
dc.subjectBilayer designen_US
dc.subjectRheological propertiesen_US
dc.titleSynthesis and Characterization of Chitosan-Acrylic Acid Based Hydrogels and Investigation the Properties of Bilayered Design with Incorporated Alginate Beadsen_US
dc.typeinfo:eu-repo/semantics/article
dc.identifier.scopus2-s2.0-85130199790
dc.identifier.wos000796325000002
dc.identifier.doi10.1007/s10924-022-02473-7


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