Targeted delivery of antitumor drugs employing biodegradable carriers- ABIDERS
SR
Moderan pristup terapiji malignih oboljenja stavlja akcenat na prilagođavanje tretmana svakom pacijentu ponaosob, uzimajući u obzir njegovo opšte zdravstveno stanje, i na precizno usmeravanje lekova na područje tumora, uz smanjenje neželjenih efekata hemioterapije. Da bi lekovi efikasno dospeli do malignih ćelija, neophodno je da nosač koji ih obavija bude biorazgradiv, ali i dovoljno otporan na spoljašnje faktore. Takođe, nosač mora biti neosetljiv na promene pH vrednosti okoline i dovoljno selektivan kako bi mogao da prođe kroz ćelijsku membranu malignih ćelija.
Cilj projekta je proizvodnja nosača od biorazgradivih materijala poput inulina i dekstrana, u koje će se inkorporirati hemioterapijski agensi koji se koriste u kliničkoj praksi. Inulin i dekstran su prirodni polimeri koji se koriste u prehrambenoj industriji i nemaju štetne efekte na organizam, što ih čini pogodnim za kreiranje biorazgradivih nosača.
EN
The modern approach to the treatment of malignant diseases tends to focus on the individual patient, their general state of health and the targeted administration of drugs to the site of malignancy with as few side effects as possible associated with chemotherapy. The targeted administration of drugs requires that the protective envelope around the drug itself must be biodegradable but at the same time resistant to various external influences for the drug to reach the malignant cells. The envelope should be inert to changes in the pH value of the environment and sufficiently selective to pass through the cell membrane of the malignant cells.
The aim of the project is to produce carriers made of biodegradable materials such as inulin and dextran, into which chemotherapeutic agents used in clinical practice are to be incorporated. Inulin and dextran are natural polymers used in the food industry and have no harmful effects on the body, which is the main reason for their selection as biodegradable carriers.
Link ka stranici projekta: https://www.mefos.unios.hr/index.php/hr/abiders
(Hrvatska-Srbija)
Identifikacioni broj projekta: HR-RS00148
Početak projekta: 01.07.2024. godine
Kraj projekta: 31.12.2025. godine
Ukupna vrednost projekta: 286.697,15 €
Intenzitet podrške: 85% (243.697,15 €)
Vodeći korisnik: Sveučilište Josipa Jurja Strossmayera u Osijeku - Medicinski fakultet Osijek
Korisnik 1: Naučni institut za prehrambene tehnologije u Novom Sadu, Univerzitet u Novom Sadu
Kontakt informacije:
Naučni institut za prehrambene tehnologije u Novom Sadu, Univerzitet u Novom Sadu
Adresa: Bulevar cara Lazara 1, 21000 Novi Sad, Republika Srbija
Kontakt osoba: dr Aleksandra Torbica
Email: aleksandra.torbica@fins.uns.ac.rs
Telefon: +381 21/485-3625;
Mobilni: +381 63/771-6522
(Croatia-Serbia)
Project Identification Number: HR-RS00148
Project Start Date: 01.07.2024
Project End Date: 31.12.2025
Total Project Value: €286,697.15
Support Intensity: 85% (€243,697.15)
Lead Beneficiary: Josip Juraj Strossmayer University of Osijek - Faculty of Medicine Osijek
Beneficiary 1: Institute of Food Technology in Novi Sad, University of Novi Sad
Contact Information:
Institute of Food Technology in Novi Sad, University of Novi Sad
Address: Bulevar cara Lazara 1, 21000 Novi Sad, Republic of Serbia
Contact Person: Dr. Aleksandra Torbica
Email: aleksandra.torbica@fins.uns.ac.rs
Phone: +381 21/485-3625
Mobile: +381 63/771-6522